Furosemide
Class
Diuretic
Description
Furosemide is a potent diuretic that inhibits the reabsorption of sodium and
chloride in theproximal tubule, distal tubule, and the loop of Henle.
Onset & Duration
Onset: (PO) 30-60 min.; (IV) 5 min.
Duration: 2 hrs
Indications
1. Edema
2. Congestive heart failure
Contraindications
1. Anuria
2. Hypersensitivity
3. Sulfa allergy
Adverse Reactions
1. Hypotension
2. Dehydration
3. Dry mouth
4. Ototoxicity (hearing loss with too rapid IV administration)
5. Tinnitus
6. Hypochloremia
7. Hypokalemia
8. Hyponatremia
9. Hyperglycemia
Drug Interactions
1. Digitalis toxicity may be potentiated by the potassium depletion that can
result from furosemide administration.
2. Increases the ototoxic potential of aminoglycoside antibiotics
3. Lithium toxicity may be potentiated by sodium depletion.
Special Considerations
1. Pregnancy safety: Category C
2. Furosemide has been known to cause fetal abnormalities
3. Should be protected from light.
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